SOUTH SAN FRANCISCO, Calif., May 13, 2025--Encoded Therapeutics Inc., a clinical-stage biotechnology company developing genetic medicines for severe central nervous system (CNS) disorders, today ...

“Pathogenic variants in the gene SCN9A, which encodes the voltage-gated sodium channel NaV1.7, cause pain insensitivity if the variant leads to loss of channel function, or hyperalgesia if the ...

Individuals with loss-of-function mutations in the SCN9A gene (which encodes the alpha-subunit of Na V 1.7) experience a complete inability to sense pain (Cox et al., 2006) while those with a gain ...

Sangamo Therapeutics, Inc. (NASDAQ:SGMO) Q4 2024 Earnings Call Transcript March 17, 2025 Sangamo Therapeutics, Inc. misses on earnings expectations. Reported EPS is $-0.11 EPS, expectations were ...

According to the release, ST-503 utilizes an adeno-associated virus vector as well as an engineered zinc finger repressor to specifically target a specific gene, SCN9A, that encodes the Nav1.7 ...

Sangamo plans to initiate enrollment of patients in the Phase 1/2 study for ST-503 in mid-2025. RICHMOND, Calif.--(BUSINESS WIRE)--Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicine company ...

The SCN9A gene builds sodium channels that help nerve cells communicate—in particular, it helps the cells alert the nervous system to a painful threat from damaged tissue.

The SCN9A gene builds sodium channels that help nerve cells communicate—in particular, it helps the cells alert the nervous system to a painful threat from damaged tissue.

Researchers performed a retrospective study to compare brain morphology of pain in small fiber neuropathy (SFN) patients with and without an SCN9A gain-of-function variant to healthy controls.. The ...

The following is a summary of “Peripheral Pain Captured Centrally: Altered Brain Morphology on MRI in Small Fiber Neuropathy Patients With and Without an SCN9A Gene Variant,” published in the November ...

Genetic variants inherited from Neanderthals make modern-day people more likely to suffer pain when poked with a stick, geneticists have found.. The Neanderthal variants involve three small changes to ...

The SCN9A gene encodes a sodium channel that is expressed at high levels in sensory neurons that detect signals from damaged tissue. The study authors found that the D1908G variant of the gene was ...