Moreover, she went on to present another poster, focused on: “Analyzing the Predicted Impact of Published SCN5A Variants in Juvenile-Onset Sick Sinus Syndrome”, at the 2024 American Heart Association ...

SCN5A is a primary candidate for arrythmias in this condition." Dr. Larissa Nitschke, first author, postdoctoral associate in the Cooper lab.

A 5-year-old Connecticut boy suffered a fatal collapse during school recess -- as nearby teachers ignored him, thinking he was pretending to "play dead," a new lawsuit charges.

Eighteen SCN5A mutations are considered pathogenic variants for DCM, such as p.D1275N used in this study. However, it remains to be determined whether AAV9-MOG1 gene therapy can be extended to ...

SCN5A is a carrier of Na + ion channels located on the cell surface, which is essential for the cardiac potential regulation ().Mutations in the SCN5A gene may increase the risk of certain heart ...

Figure 1. Effect of Allicin on the I Na,L of the ΔKPQ-SCN5A mutation. (A,B) Representative current traces recorded.I Na,L of ΔKPQ-SCN5A was significantly larger than that of WT, which was inhibited by ...

The syndrome is associated with discrete arrhythmogenic substrate in the epicardium of the right ventricle. The findings of this study suggest that SCN5A mutation is associated with a larger ...

Use of unproven COVID-19 therapeutics, such as hydroxychloroquine, could increase the risk of developing cardiac complications in African-American populations. Now, researchers have urged caution as a ...

The African-specific p.Ser1103Tyr-SCN5A common ion channel variant is a reasonable place to start, as its proarrhythmic potential is awakened by risk factors observed in hospitalized COVID-19 ...

Irritable bowel syndrome (IBS) is a common disorder of the large intestine resulting in cramping, bloating, abdominal pain, mucus in the colon, gas, and diarrhea or constipation or even both. It ...

Missplicing Scn5a alters cardiac function Using CRISPR technology, Cooper and his colleagues removed the gene segment containing the adult form of Scn5a. Consequently, the developing mice ...

A team of researchers at Baylor College of Medicine reveals new insights into what can be causing life-threatening cardiac-related events in myotonic dystrophy type 1(DM1). Published in the ...