Genetic analysis focused on five genes known to influence prostate cancer risk: BRCA1, BRCA2, HOXB13, RNASEL, and ELAC2. Only BRCA2 and HOXB13 showed a strong statistical association with cancer.

Genetic mutations passed down through families cause up to 12% of prostate cancers. Genetic testing could provide information that changes your treatment and future health decisions. But it’s ...

R code for the RNAse L manuscript. Contribute to TriLab-bioinf/TK_65_RNAseL_manuscript development by creating an account on GitHub.

Importantly, risk grouping using ribosome biogenesis-related genes was also closely associated with important signaling pathways in stroke. ELISA detected the expression of C1QBP, RPS28 and RNASEL ...

Genetic factors are one of the significant contributors to prostate cancer (PCa) development. The objective of the present study was to analyze the carriage of the C650T (Ser217Leu) and G1621A ...

Neurodegeneration in Parkinson's disease (PD) precedes diagnosis by years. Early neurodegeneration may be reflected in RNA levels and measurable as a biomarker. Here, we present the largest ...

Notably, autosomal recessive (AR) deficiencies of OAS1, OAS2, and RNASEL were determined as the genetic etiologies of MIS-C in P1-P5.

Researchers assessed the inborn abnormalities of 2′-5′-oligoadenylate synthetase (OAS)-ribonuclease L (RNASEL) noted in coronavirus disease 2019 (COVID-19)-associated multisystem inflammatory ...

The first results obtained by studying a large sample of children presenting MIS-C made it possible to identify recessive defective variants on the OAS1, OAS2 or RNASEL genes (implicated in the ...

We further test if activation of antiviral innate immune responses with a dsRNA mimetic, Poly I:C (PI:C) induces similar effects in uninfected hearts and in human iPSC-derived cardiomyocytes ...

Of note, the antiviral effector RNASEL is also a member of this network. IRF1 Dependent Genes Protect Against VSV Infection Several anti-viral genes are constitutively expressed at lower levels in the ...