Regulation of GPCR signaling by RGS12. The Gβγ heterodimer serves to couple Gα to the receptor and to inhibit its spontaneous release of GDP. Overview of RGS12 expression in various human diseases.

Regulation of GPCR signaling by RGS12. The Gβγ heterodimer serves to couple Gα to the receptor and to inhibit its spontaneous release of GDP. Overview of RGS12 expression in various... "Lorem ipsum ...

Regulation of GPCR signaling by RGS12. The Gβγ heterodimer serves to couple Gα to the receptor and to inhibit its spontaneous release of GDP. Overview of RGS12 expression in various human diseases.

dDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA eDivision of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic, Jacksonville, FL, USA Transcriptomic ...

Our analysis implicated the causative variant in RGS12, a gene that controls Ca 2+ oscillation, which is required for oocyte activation after fertilization. This study was approved by the Ethics ...

In a validation cohort of 62 LN patients and 21 healthy controls (HC), we found that prolyl 3-hydroxylase 1 (P3H1), phosphatase and actin regulator 4 (PHACTR4), and regulator of G-protein signaling 12 ...

We previously demonstrated that Rgs12 is essential for osteoclast differentiation and its deletion in vivo protected mice against pathological bone loss. To characterize its mechanism in ...

The Rgs12 gene drives the development of the cells that break down bones by allowing the cell to accumulate highly unstable derivatives of oxygen associated with aging. Open annotations (there are ...

Dysregulation of signaling via heterotrimeric G proteins leads to pathogenesis. Thus, developing an efficient armamentarium to study G protein regulation is crucial for understanding the molecular ...