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Frontiers1mon
Explore potential immune-related targets of leeches in the treatment of type 2 diabetes based on network pharmacology and machine learning
Results: Leeches may influence cellular immunity by modulating immune receptor activity, particularly through the activation of RGS10, CAPS2, and OPA1, thereby impacting the pathology of Type 2 ...
The EMBO Journal4mon
RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Small GTPase RHEB is a well-known mTORC1 ...
C&EN6mon
A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells
Regulator of G protein Signaling 10 (RGS10) is highly expressed in microglia, where it suppresses pro-inflammatory signaling. However, RGS10 is silenced following microglial activation, augmenting ...
eLife9mon
RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer
The paper has shown the expression of RGS10 is related to the molecular subtype, distant metastasis, and survival status of breast cancer. The study utilizes bioinformatic analyses, human tissue ...
eLife1y
RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer
Data were derived from the Genotype-Tissue Expression database. (B) RGS10 mRNA levels in cell lines representing 21 human cancers. Data were derived from the Cancer Cell Line Encyclopedia database. (C ...
The Lancet1y
Time-to-progression after front-line fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy for chronic lymphocytic leukaemia: a retrospective, multicohort study
bDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA cDepartment of Internal Medicine, The Ohio State University, Columbus, OH, USA dDepartment of Pathology, The Ohio ...
The EMBO Journal1y
A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This resource provides a comprehensive and ...
GitHub1y
Mapping_Comparison_fixed.md
Single Cell Analysis with Seurat and some custom code! Seurat is a popular R package that is designed for QC, analysis, and exploration of single cell data. Seurat aims to enable users to identify and ...
Frontiers3y
Effect of Regulator of G Protein Signaling Proteins on Bone
Regulator of G protein signaling (RGS) proteins are critical negative molecules of G protein-coupled receptor (GPCR) signaling, which mediates a variety of biological processes in bone homeostasis and ...
The Lancet7y
A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts
bLaboratoire d'Hématologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France cService d'Anatomie Pathologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, ...
ahajournals.org9y
Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase–Extracellular Signal-Regulated Protein Kinase 1/2 ...
Regulator of G-protein signaling 10 (RGS10) is an important member of the RGS family and produces biological effects in multiple organs. We used a genetic approach to study the role of RGS10 in the ...