Heterogeneity in response to treatment of pulmonary arterial hypertension (PAH) is a major challenge to improving outcome in this disease. Although vasodilator-responsive PAH (VR-PAH) accounts for a ...

Among all the validated target genes, we observed a significant increase of NRCAM (FC = 1.20, p-value = 0.027), IL4R (FC = 1.26, p-value = 0.046), and RAPGEF2 (FC = 1.23, p-value = 0.020).We suggest ...

INFO [2022-12-09 16:50:33] Less cells in group unassigned than k_nn setting. Keeping as a single subcluster.

A multi-institutional, large-scale meta-analysis identified 7 novel genome-wide significant loci in patients with idiopathic pulmonary fibrosis (IPF), many of which were associated with lung function ...

Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network heterogeneity and compensatory network activation. Here, we show that targeting driver network signaling ...

RAPGEF2(Rap guanin nucleotide exchange factor 2) is an essential protein involved in multiple critical biological pathways such as synaptic remodeling, neural plasticity, and embryo neural ...

Title) RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease Alzheimer's disease (AD) accounts for about 75% of dementia ...

RAPGEF2(Rap guanin nucleotide exchange factor 2) is an essential protein involved in multiple critical biological pathways such as synaptic remodeling, neural plasticity, and embryo neural development ...

DSCAM starts to be expressed in differentiated neurons only before migration and locally suppresses the RapGEF2–Rap1–Cdh2 cascade at their apical endfeet to delaminate (Arimura et al., 2020). The ...

The GTPases of the Ras superfamily regulate cell growth, membrane traffic and the cytoskeleton, and a wide range of diseases are caused by mutations in particular members. They function as switchable ...

Maintenance of lymphatic permeability is essential for normal lymphatic function during adulthood, but the precise signaling pathways that control lymphatic junctions during development are not fully ...