BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

It also sought the use of a “new RAF1” claim form. “Unfortunately, the manner in which these changes were sought to be implemented, apart from being grossly misguided, was hopelessly flawed.

In contrast to RKIP, which disrupts the RAF1–MEK interaction, PEBP4 forms ternary complexes with RAF1 and MEK, and can scaffold this interaction. PEBP4 expression is induced during the differentiation ...

The research team found that Raf1 and Raf2, although acting at different steps of Rubisco assembly, could independently enhance Rubisco abundance and plant performance. This opens possibilities ...

A three-dimensional image showing the human protein KRAS (blue) interacting with RAF1 (yellow), one of its main partners. The blue-to-red color gradient indicates increasing potential for allosteric ...

The cDNAs encoding RAF1 mutants were generated by PCR and inserted into pCDNA3.1(+) vector with N-terminal FLAG tag. Plasmids were transfected into 293T cells by using lipofectamine 2000 (Invitrogen), ...

An illustrative image of financing. Quanta Therapeutics has closed a Series D financing round, which raised more than $50 million. Image Credit: Getty Images / Olivier Le Moal Quanta Therapeutics has ...

Novel therapeutics are urgently needed, especially for tumours with activating mutations in KRAS (∼40%). Here we investigated the role of RAF1 in CRC, as a potential, novel target. Methods ...

New York, Jan. 24, 2023 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "RAF Proto Oncogene Serine, Threonine Protein Kinase (Proto Oncogene c RAF or RAF1 or EC 2.7.11.1 ...

Beyond the development of drugs against KRAS, one of the most active research areas at the moment seeks to identify inhibitors of proteins, such as RAF1, responsible for transmitting the KRAS ...