This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

Human NR3 nuclear receptors translate ... revealing the molecular mechanisms of diverse ligand binding and allosteric activation of AHR. Structural and cellular assays and molecular dynamics ...

Objectives Tendinopathy is a frequent clinical problem and represents an extraordinary health economic and socioeconomic burden with high unmet medical needs. Recent clinical evidence suggests ...

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent nuclear receptor that has ... resulted in an increase in DiI-OxLDL binding to wild-type macrophages (data not shown ...

However, invertebrates such as Drosophila indirectly recognize microbial products by binding to the cytokine-like ligand Spätzle ... complex contributes to Dorsal-L phosphorylation and nuclear ...

GMP Human 4-1BB Ligand Protein, Fc Tag (Cat. No. GMP-41LH26) is stable at 37 °C for 16 hours, according to the cell-based assay. Image Credit: ACROBiosystems GMP Human 4-1BB Ligand Protein ...

Nuclear binding energies of neutron-rich radioactive nuclei are essential inputs for calculations addressing the origin of heavy elements in the Cosmos. Recently, researchers at the Accelerator ...

MST assays are used to optimize protein-ligand interactions or assess the impact of mutations on binding affinities during protein engineering projects. DNA and RNA Research: MST can measure DNA-DNA, ...

Perhaps even more vulnerable are the startups and power producers that are betting big on new nuclear and natural gas capacity. Nuclear power, in particular, has been on the cusp of a ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

The influenza A virus genome consists of eight segments of single-stranded, negative-sense viral RNA, which encode multiple ...