A new study in Nature Aging reveals how nucleolar enlargement can act as a biological “timer” that drives catastrophic genome ...

When normal DNA repair systems are broken, as in BRCA-deficient cancers, cells rely on backup proteins like RAD52 to keep growing. If RAD52 is blocked, the cancer cells can’t fix their DNA and die.

“RAD52 is a coveted drug target for treating cancers that have DNA repair deficiencies, including breast and ovarian cancers, and some glioblastomas,” explains Maria Spies, PhD, professor of ...

When cancer cells lose one way to repair their DNA, they quickly find another. That workaround often involves RAD52 — a protein now squarely in the sights of researchers hunting for new anti ...

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and ...

The fact that RAD52 appears to be dispensable in normal human cells but essential for survival of cancer cells experiencing defective DNA repair creates both an advantage and a challenge. The ...

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and ...

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Introduction. Rad52 was first identified along with a large group of homologous recombination (HR) proteins in a screen for DNA-repair deficient S. cerevisiae mutants following ionizing radiation ...