Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated ...

The research team used advanced proteomic analysis to uncover that when aVb6 integrin is activated, it recruits HER2 along with a network of molecules known as RAB5, RAB7A and GDI2. This network ...

By targeting the RAB5/RAB7A/GDI2 module or restoring its normal function, it may be possible to prevent or delay the onset of resistance in HER2-positive breast cancers. Moreover, monitoring α V ...

The research team used advanced proteomic analysis to uncover that when αVβ6 integrin is activated, it recruits HER2 along with a network of molecules known as RAB5, RAB7A and GDI2. This network ...

As the researchers demonstrate, the interplay of two proteins – the ion channel TPC2 and the enzyme Rab7a – plays a decisive role, as they promote the growth and metastasis of melanoma. Studies have ...

The researchers focused on a protein called TPC2 and an enzyme called Rab7a. These two proteins are part of the cell’s “recycling system,” known as the endolysosomal system. This system ...

As the researchers demonstrate, the interplay of two proteins – the ion channel TPC2 and the enzyme Rab7a – plays a decisive role, as they promote the growth and metastasis of melanoma. Studies have ...

As the researchers demonstrate, the interplay of two proteins -- the ion channel TPC2 and the enzyme Rab7a -- plays a decisive role, as they promote the growth and metastasis of melanoma.