NEW YORK — Verizon will be recognized as the 2025 Radio Mercury Awards’ “Marketer of the Year” in recognition of the company’s commitment to radio as a lead medium. “From their ...

Overexpression of Rab7 could partially overcome this block, even in the absence of SAND-1 or CCZ1, suggesting the presence of a second Rab7 GEF. Our data reveal a hierarchy of events in which cargo ...

Rab GTPases play essential roles in intracellular trafficking ... With the sequence features of a GTP-locked active GTPase, Rsg1 may be a constitutive subunit of CPLANE required for GEF activity or ...

For instance, there is evidence that modulators of Rho GTPases (such as ITSN, a selective Cdc42 GEF) also participate in the Rab-mediated intracellular trafficking process in neurodegenerative ...

2017). As discussed earlier, RIN3, as a Rab5 GEF, regulates Rab5 GTPase to impact intracellular transport pathways. Rab GTPases have been strongly implicated in the regulation of osteoclast function ...

Based on the fact that Ypt10p binds Mon1-Ccz1 with higher affinity than other Rab proteins, one would expect the enhancement of GEF activity to be caused by more Mon1-Ccz1 bound to the liposome.

For DENND1-Rab35 and DrrA-Rab1 the Rab active-site glutamine, often mutated to create constitutively active forms, is involved in GEF mediated GDP-release. By contrast, in Rab5 the switch II aspartate ...