Circulating tumor cell RNA biomarker for bavdegalutamide (ARV-110) in metastatic castration-resistant prostate cancer without AR T878/H875 mutations. This is an ASCO Meeting Abstract from the 2025 ...

(I) IWP-2 did not increase the endogenous FZD5 protein level in ZRDKO cells. (J) RSPO1 failed to increase the level of the mature form of FZD5 in ZRDKO cells. FZD5KI and ZRDKO-FZD5KI cells were ...

11 Therefore, we also hypothesized that this signal would contribute to neurite outgrowth. To test these hypotheses, we first examined the temporal profile of RSPO1, RSPO3, and LGR4 in the ischemic ...

This study demonstrates that NGS-MSI is noninferior to IHC-MMR and can identify MSI-H tumors that IHC-MMR is unable to detect and conversely IHC-MMR can identify MMRd tumors that NGS-MSI misses. This ...

They play roles in multiple processes during vertebrate development. Rspo1, a member of R-spondin family, regulates sex differentiation in both mammals (e.g. mouse) and reptiles (e.g. turtle). However ...

bDepartment of Biomedicine, University Hospital and University of Basel, CH-4031, Basel, Switzerland cClarunis University Center for Gastrointestinal and Liver Diseases, CH-4002, Basel, Switzerland ...

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Additional growth factors, including EGF, Noggin (NOG), R-spondin (RSPO1), and HGF, are also key components of organoid media. The necessary combinations of these growth factors are contingent on ...

The development process of organoids begins with the extraction of adult stem cells or pluripotent stem cells from an organ, followed by their incubation in a specialised in vitro environment ...