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C&EN1mon
Probing the Degree of Restriction in Solvent Dynamics at the Interface of a Protein–RNA Complex
In particular, water molecules around the protein’s linker, RRM2, and the RNA strand exhibit significantly more restricted motion compared to RRM1 upon complexation. Further, longer relaxation times ...
UroToday6mon
High RRM2 Correlates with Mitochondrial and Immune Responses in the Eosinophilic Subtype of Clear Cell Renal Cell Carcinoma.
RRM2 emerged as the most prognostic gene from this risk score, particularly in the eosinophilic subtype, alongside other clinical variables. By IHC, RRM2 shows high IHC score in eosinophilic compared ...
Scientific Research Publishing7mon
Fang, Y.J., Ruan, X.G., Zhang, X.Q., et al. (2023) The Expression of RRM2 and ANXA1 in Renal Cell Carcinoma and Its Relationship with the Prognosis of Patients. Shandong ...
Five core genes NCAPG, MAD2L1, CDK1, RRM2 and RFC4 were screened from the PPI network. The five genes were highly expressed in sarcoma. Conclusion: The five core common differentially expressed genes ...
Scientific Research Publishing7mon
Fu, K., Zhang, K. and Zhang, X. (2022) LncRNA HOTAIR Facilitates Proliferation and Represses Apoptosis of Retinoblastoma Cells through the miR-20b-5p/RRM2/PI3K/AKT Axis ...
Five core genes NCAPG, MAD2L1, CDK1, RRM2 and RFC4 were screened from the PPI network. The five genes were highly expressed in sarcoma. Conclusion: The five core common differentially expressed genes ...
C&EN7mon
Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach
Truncated variants of human MSI1 encompassing the two homologous RNA recognition motifs (RRM1 and RRM2) in tandem (aa 1–200), and the two RRMs in isolation (aa 1–103 and aa 104–200, respectively) were ...
Pharmaceutical Technology11mon
Dsrna for inhibiting rrm2 gene expression
A recently granted patent (Publication Number: US11920134B2) discloses a double-stranded ribonucleic acid molecule designed to inhibit the expression of a ribonucleotide reductase M2 (RRM2) gene. The ...
Frontiers2y
Over-expression of RRM2 predicts adverse prognosis correlated with immune infiltrates: A potential biomarker for hepatocellular carcinoma
Background: Ribonucleotide reductase regulatory subunit M2 (RRM2) has been reported to be an oncogene in some malignant tumors, such as lung adenocarcinoma, oral squamous cell carcinoma, glioblastoma, ...
News Medical2y
Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response
The team also noted that the depletion of CHK1 was sufficient to decrease RRM2 levels and result in DNA damage. Moreover, CHK1 knockdown resulted in the activation of STAT1 and P38 as well as the ...
eLife2y
Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM)
Moreover, ribonucleotide reductase regulatory subunit M2 (RRM2) was found and verified to promote proliferation of MM cell lines, suggesting RRM2 may serve as a detrimental marker in MM. The ...
Phys.org2y
Unusual RNA binding properties found in protein essential for germ cell survival
The affinity of RRM1 for a single short RNA increased by a factor 80x in the presence of RRM2. The NMR structure revealed the binding consensus sequence and several unusual RNA recognition ...
Baylor College of Medicine3y
Nagireddy Putluri, Ph.D
My research is centered on leveraging advanced mass spectrometry technologies to investigate metabolic reprogramming in cancer development and progression. I have established a robust and independent ...