"These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory," said Mark Dell'Acqua, professor of ...

The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...

Today, Canada alongside other G7 RRM members (European Union, France, Germany, Italy, Japan, the United Kingdom, the United States) as well as G7 RRM Observer states (Australia, Netherlands, New ...

But the exact mechanism is still unclear ... the enzymatic action of citrate synthase (CS), which catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate. This generated citrate then ...

Pyruvate conversion to oxaloacetate and use as a gluconeogenic substrate restrains ... This led us to hypothesize the existence of a feedback mechanism that senses inappropriate reductions in cell ...