Herein, we conduct structural and functional analyses of how Hook3 mediates KIF1C-dependent anterograde cargo transport through interaction with KIF1C and PTPN21. We verify the interactions among the ...

Carotid intima‐media thickness (IMT) is a measure of atherosclerosis and a predictor of vascular diseases. Traditional vascular risk factors and genetic variants do not completely explain the ...

Central European Journal of Immunology is published under patronage Committee for Immunology and Etiology of Human Infections, Polish Academy of Sciences. Now in ...

School of Public Health, Shanxi Medical University, China The First Clinical Medical College, Shanxi Medical University, China Department of Pathology, The First Hospital, Shanxi Medical University, ...

Pseudophosphatases in non-receptor PTPs include non-receptor tyrosine protein kinase 23 (HD-PTP/PTPN23), non-receptor tyrosine protein kinase 14 (PTPN14) and non-receptor tyrosine protein kinase 21 ...

Binding of a protein called PTPN21 or Hook3 changes conformation (shape) of KIF1C to expose its binding domains, thereby allowing it to bind to microtubules and act as a molecular motor in the ...

and PTPN21. The WW tandem-mediated target recognition mechanisms elucidated here can guide functional studies of WW domain proteins in cell growth and polarity as well as in other cellular processes ...

A new study reported in Nature Communications has discovered activators for molecules that act as motors to move materials around within nerve cells. Nerve cells form the basis of the nervous ...

Scientists at the University of Warwick have discovered a new process that sets the fastest molecular motor on its marathon-like runs through our neurons. The findings, now published in Nature ...