White et al. injected anti-PrP monoclonal antibodies with high affinity for both murine PrPC and PrPSc into individual mice from a scrapie model strain. They observed that peripheral PrPSc levels and ...

The research also uncovered species-specific SNPs. For instance, three SNPs (G34C, T699C, and C738G) were unique to Nigerian dogs, while four others (C16G, G502A, G503A, and C681A) were found only ...

It is a small molecule oligomer modulator and aggregation inhibitor and is administered orally. The drug blocks the formation of pathological aggregates of prion protein (PrPSc) and of a-synuclein ...

Prion diseases are rare, fatal brain disorders in humans and animals caused by the accumulation of an abnormal protein (PrPSc) that leads to brain degeneration and neurological decline. Learn More on ...

PrPSc also replicates like an inanimate crystal; devoid of genetic material, PrPSc auto-catalyzes and triggers a chain-like reaction to produce more of itself.

Investigators detected prions in one of 75 cadavers received by an institution in Japan for anatomical practice, according to a letter published in the New England Journal of Medicine. "The ...

The novel PrPSc oligomers are partially fragmented by quaking, producing novel seeds while, in part, they continue to elongate up to the status of protofibrils and eventually fibrils. By acquiring ...

A autópsia revelou imuno-histoquímica positiva para a proteína PrPSc. A doença de Creutzfeldt-Jakob que se apresenta com perda auditiva é incomum. Palavras-chave: demência; doença de príon; hypoacusis ...