A study led by the University of Cincinnati Cancer Center reveals how the MYC oncogene accelerates lymphoma growth through the PRPS enzyme, prompting potential targeted treatments.

A study led by researchers at the University of Cincinnati Cancer Center provides new insights into how a key oncogene contributes to the development and progression of lymphoma, potentially informing ...

Eliminating PRPS1’s function enhanced sensitivity to oxidative stressors and damage within cells, while eliminating PRPS2’s function triggered reductive stress. Essentially, the team found that MYC ...

PRPS1 loss increases sensitivity to oxidative stress, while PRPS2 loss induces reductive stress. Targeting PRPS disrupts redox balance, offering a potential strategy for novel lymphoma therapies.

In contrast, loss of function mutations in PRPS1, which cause a spectrum of diseases with clinical features of diverse severity, including neurodegeneration, likely results from depletion of purine ...

Glucose, even though the primary energy source for most cells, cannot traverse the cellular lipid membrane simply by diffusion, due to its polarity and large size. 7 Two main types of glucose ...

Tests revealed he had the genetic defect, PRPS1, which has resulted in him being blind and having severe hearing loss. However, further devastating news was to follow when at four months old, ...

Kind strangers have started fundraising for treatment for 11-month-old Grayson Bell, who is believed to be the 'only boy in the UK with Arts Syndrome', after parents' desperate plea for NHS help ...

Grayson Bell has been diagnosed with a PRPS1 gene and Arts Syndrome, which can lead to death during childhood. The 11 month old tot is unable to see or hear and has a weak muscle tone, which means ...