Grid testing confirmed muscle strength preservation, while gene expression analysis revealed upregulation of PLIN4, GLUT transporters, and IRS1. Notably, cFos mapping demonstrated activation of ...

Heart failure with preserved ejection fraction (HFpEF) accounts for more than half of heart failure cases worldwide. Obesity and metabolic syndrome are major drivers of HFpEF pathophysiology resulting ...

Integrating polygenic risk scores into clinical breast cancer models: Influence on prediction in diverse cohorts.

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Cytoplasmic lipid droplets are highly dynamic storage organelles that are critical for cellular lipid homeostasis. While the molecular details of lipid droplet dynamics are a very active area of ...

A striking example is Plin4, whose gigantic and repetitive AH lacks bulky hydrophobic residues. Using a range of complementary approaches, we show that Plin4 forms a remarkably immobile and stable ...

Finally, RT-PCR and LC-MS/MS were used to detect the mRNA and protein expressions of FABP5, Plin4, GPD1, and AGPAT2, respectively. Results: Although silibinin did not reduce the mice's weight, it did ...