Breast cancer – ULK3, ASIP, CSK, TLR1; 2. Luminal A – ADH5, ULK3, SARS2, UBE2N; 3. Luminal B – PEX14. Six of the nine robust proteins were supported by murine phenotype data, confirming ...

HIF (hypoxia inducible factor) regulates many aspects of cardiac function. We and others previously showed that chronic HIF activation in the heart in mouse models phenocopies multiple features of ...

In the ER-negative breast cancer, PEX14 showed strong genetic colocalization evidence in protein (PPH4 = 99.9%) and breast mammary tissue (PPH4 = 88.8%), but this pattern was not replicated at the ...

How environmental cues influence peroxisome proliferation, particularly through organelles, remains largely unknown. Yeast peroxisomes metabolize fatty acids (FA), and methylotrophic yeasts also ...

Human PEX5 and PEX14 are essential components of the peroxisomal translocon, which mediates import of cargo enzymes into peroxisomes. PEX5 is a soluble receptor for cargo enzymes comprised of an ...

The authors identify peroxide-triggered phosphorylation sites on Pex14 and show that phosphorylation at one such site impairs catalase import. A series of in vitro experiments suggests that ...

In this study, we demonstrate that skin fibroblasts from ZS patients and PEX1‐ and PEX14‐deficient hTERT‐immortalized human retinal pigment epithelial (hTERT‐RPE1) cells generated using CRISPR/Cas9 ...

Center for Integrated Protein Science Munich at Chair of Biomolecular NMR, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany ...

The researchers identified 16 genome-wide significant variants associated with grip strength — within or near POLD3, TGFA, ERP27, HOXB3, GLIS1, PEX14, MGMT, LRPPRC, SYT1, GBF1, KANSL1, SLC8A1, IGSF9B, ...