CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic ...

The pore-forming activity of perforin is exquisitely pH-dependent, being most potent at neutral pH. Under these conditions, perforin monomers bind the lipid membrane in a calcium-dependent fashion ...

By stretching and bending the membranes of tumor cells in a certain direction, T cells made it easier for perforin to punch through, but only if the membranes were bent in the right direction.

Perforin punctures tiny holes in the outer membrane of the targeted aberrant cell. Granzymes, which are proteolytic enzymes, pass through the openings and induce programmed cell death (apoptosis).

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Perforin-like proteins (PLPs) are also found in apicomplexan parasites. Here they play diverse roles during lifecycle progression of the intracellularly replicating protozoans. The apicomplexan PLPs ...

Figure 1.Perforin deficiency accelerates liver injury and enhances lipid accumulation in 14 month-old mice. (A) Liver weight was determined for WT and Prf −/− mice on a normal chow diet (n = 4–5). (B) ...

Then they use these perforin channels to pour in toxic granzyme B, which induces the cells to self-destruct. Mutations in the genes responsible for “any one of the 10-plus proteins that get perforin ...

Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer cells to help eliminate virus-infected and transformed target cells.

This paper describes the analysis of pore formation and detection of a single protein molecule using a large nanopore among five different pore-forming proteins. We demonstrate that the identification ...

BackgroundThe authors analyzed the effects of perforin‐dependent infiltration on long‐term mortality in patients with inflammatory cardiomyopathy (CMi). We previously demonstrated that left ...

It has been suggested that the heavily glycosylated and abundant glycoprotein serglycin may form complexes with perforin and negatively regulate its function within the secretory granules of the host ...