LTI-03 reduced the expression of profibrotic proteins in IPF PCLS, including Col-1α1 and platelet-derived growth factor receptor beta (PDGFRB). Unlike nintedanib, LTI-03 did not induce cellular ...

enhances signalling pathways such as PDGFRB-STAT5 or T cell receptor-associated mechanisms. These changes are suspected of promoting the development and spread of lymphomas. "Although the chances ...

enhances signaling pathways such as PDGFRB-STAT5 or T cell receptor-associated mechanisms. These changes are suspected of promoting the development and spread of lymphomas. "Although the chances ...

enhances signalling pathways such as PDGFRB-STAT5 or T cell receptor-associated mechanisms. These changes are suspected of promoting the development and spread of lymphomas. Although the chances ...

Key mutations in UCD include PDGFRB N666S, while iMCD is associated with mutations in NCOA4, SETD1A, and DNMT3A, among others. Dysregulation of genes involved in immune response, angiogenesis (e.g ...

Genetic Abnormalities in Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Fusion Genes This newly classified subgroup within the WHO-HAEM5 includes cases with eosinophilia driven by ...

a, Confocal projections of pericytes (TgBAC(pdgfrb:egfp) ncv22) and brain vasculature (Tg(kdrl:Hsa.HRAS-mCherry) s843) in sibling and pdgfrb uq30bh mutants at 7 dpf. a′, Zoomed section from a (dashed ...

Using pdgfrb mutant zebrafish models lacking brain pericytes, the authors report that pericyte-deficient cerebrovasculatures are ill-patterned, yet display unaltered restrictive BBB permeability ...

“Pediatric acute lymphoblastic leukemia patients with PDGFRB fusions are associated with high-risk clinical features such as older age, high white blood cell count at diagnosis, high measurable ...

Next, they created a mouse model of intracranial aneurysm by using an adenovirus to insert mutant PDGFRB into the basilar artery at the base of the brain. After a month, the size of the artery had ...