A complex signaling process involving paxillin, a focal adhesion protein, may be vulnerable to cancer therapy despite its ...

A team of international researchers led by scientists at City of Hope provides the most thorough account yet of an elusive ...

A team of international researchers led by scientists at City of Hope®, one of the largest and most advanced cancer research and ...

Paxillin as a link to the intracellular support system. Specialized membrane proteins—integrins—ensure cohesion in the tissue. They serve as anchoring points for the cells.

Since paxillin is present in all cells as a link between integrins and the cytoskeleton, it also serves as a marker to visualize the dot-like and line-like anchoring points, i.e. focal adhesions.

Paxillin's Role in Liver Fibrosis Transformation Unveiled. Medical University of South Carolina. Currently, the United States lacks FDA-approved treatments for liver fibrosis, highlighting the ...

Cells were fixed and paxillin was labeled as in A. Images shown are representative of at least 10 others. Paxillin-containing FAs were quantified as in A (n=5 technical replicates). Scale bar: 10 μm.

For paxillin quantifications, given that paxillin recycling is higher at the distal processes of migrating cells comprising the growth cone and that autophagy specifically affects paxillin recycling ...

When scoring paxillin, we ignored the inner cell cytoplasmic paxillin and chose to focus on the paxillin localized to the edges of the cell area. We scored a cell as containing focal adhesion ...

Furthermore, Src/FAK/Paxillin focal adhesion pathways were detected via mRNA sequencing and Western blot assays. We need to further confirm that RB functions in GBM via Src/FAK/Paxillin focal adhesion ...