(Boston)—PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting cellular ...

PAX3, a transcription factor implicated in melanoma, primarily binds DNA through its paired domain (PD) to activate genes that promote cell growth and protein synthesis, supporting cancer progression.

The researchers believe that PAX3 could be a good target for treating melanoma, but currently, there are no drugs that block the function of this protein. "Since we found that PAX3 works mostly ...

(Boston)—PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting ...

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It involves both myogenic and neural differentiation and is characterized by PAX3 rearrangement. MAML3 is the most frequent fusion partner of PAX3; however, its partner remains unidentified in a ...

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The DeKalb-Peachtree Airport director is retiring at the end of the week. Mario Evans has overseen daily operations at the state’s second-busiest airport since he was promoted from assistant ...

When Hamas attacked Israel, Republicans knew whom to blame: President Biden. Donald Trump asserted that the attack wouldn’t have happened if he were still in the White House; Mike Pence, while ...

In RMS, however, patients have genetic mutations that cause their cells to make a specific protein, called PAX3-FOXO1, which stops differentiation from happening in skeletal muscle cells.

The findings are published in the journal Proceedings of the National Academy of Sciences in an article titled, “Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3–FOXO1 ...