News

ascopubs.org1y
Anti-tumor efficacy of the Runx2-dendritic cell vaccine in triple-negative breast cancer in vitro.
IPA-3 (PAK1 inhibitor) or OTSSP167 (MELK inhibitor) plus auranofin (PKCι inhibitor), a therapeutic option for EGFR mutant, KRAS mutant and squamous cell non-small cell lung cancer (NSCLC). This is an ...
University of Sheffield1y
Energy-starved breast cancer cells consume their surroundings for fuel
Blocking or reducing expression of HPDL, or the macropinocytosis promoter PAK1, reduced the ability of tumour cells to migrate and to invade surrounding tissue. Dr Rainero added: “Our results indicate ...
Armed robbery in Revesby2y
PAK1 Gene Mutation Location Linked to IDDMSSD Syndrome Clinical Presentation
I am proud of my dedicated team and collaborators who made it possible to identify the rare genetic alteration in the gene p21-activated kinase 1 (PAK1) and expand our understanding of PAK1-related ...
Medical Xpress2y
Clinical presentation of IDDMSSD syndrome likely associated with molecular location of mutation in PAK1 gene
I am proud of my dedicated team and collaborators who made it possible to identify the rare genetic alteration in the gene p21-activated kinase 1 (PAK1) and expand our understanding of PAK1 ...
Frontiers3y
Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis
Skeletal muscle accounts for ~80% of insulin-stimulated glucose uptake. The Group I p21–activated kinase 1 (PAK1) is required for the non-canonical insulin-stimulated GLUT4 vesicle translocation in ...
eLife3y
Pak1 kinase controls cell shape through ribonucleoprotein granules
We discovered a mechanism linking the conserved protein kinase Pak1 with cell shape through the RNA-binding protein Sts5. Pak1 (also called Shk1 and Orb2) prevents Sts5 association with P bodies by ...
eLife3y
Pak1 kinase controls cell shape through ribonucleoprotein granules
The key molecule investigated is the highly conserved Pak1 kinase (well characterized as a Cdc42 GTPase effector). The paper brings together investigation of sts5, pak1-kinase and how these together ...
Frontiers3y
PAK1 Mediates Bone Marrow Stromal Cell-Induced Drug Resistance in Acute Myeloid Leukemia via ERK1/2 Signaling Pathway
This study was designed to investigate the role of p21-activated kinase 1 (PAK1) in AML progression and chemosensitivity, highlighting the mechanism of stroma-mediated chemoresistance. Methods: The ...
archive4y
PVZ FVM 2.0
EMBED <iframe src="https://archive.org/embed/pvz-fvm-2.0" width="560" height="384" frameborder="0" webkitallowfullscreen="true" mozallowfullscreen="true ...
ascopubs.org7y
Effect of cabazitaxel regimens on the growth of prostate cancer cells and the antitumor properties of PEDF.
IPA-3 (PAK1 inhibitor) or OTSSP167 (MELK inhibitor) plus auranofin (PKCι inhibitor), a therapeutic option for EGFR mutant, KRAS mutant and squamous cell non-small cell lung cancer (NSCLC). This is an ...
Snopes.com8y
"Sour Honey' is a Cure for Cancer?
1 September 2011. Messerli, S.M., et al. "Artepillin C (ARC) in Brazilian Green Propolis Selectively Blocks Oncogenic PAK1 Signaling and Suppresses the Growth of NF Tumors in Mice." ...
C&EN9y
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety
† Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States ‡ Afraxis, Inc., 6605 Nancy Ridge Road, Suite 224, San Diego, California 92121 ...