aOrganLife Organ Regeneration Centre of Excellence and Daniel Swarovski Research Laboratory (DSL), Department of Visceral, Transplant and Thoracic Surgery, Centre of Operative Medicine, Medical ...

Current therapies cannot completely reverse advanced atherosclerosis. High levels of amino acids, induced by Western diet, stimulate mTORC1 (mammalian target of rapamycin complex 1)-autophagy defects ...

Department of Food and Nutrition, Hannam University Daedeok Valley Campus, 461-6 Jeonmin-dong, Yuseong-gu, Daejeon 305-811, Korea, Department of Internal Medicine, Gyeong-Sang National University ...

Recruitment of PTPN6/11 to PD‐1 is thought to contribute to T cell exhaustion. Deletion of these phosphatases in the polyclonal T cell compartment, however, fails to improve tumor control and severely ...

aChanning Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA ...

Importantly, knockdown of HNRNPH1 in CML cells enhanced sensitivity to imatinib. Mechanically, HNRNPH1 could bind to the mRNA of PTPN6 and negatively regulated its expression. PTPN6 mediated the ...

The authors emphasize differences in the effect of knocking out PTPN6 or IL-10 in the TNF secretion induced by LPS from B. theta. The authors go on to say (line 230) "Most prominently, knockouts of ...

Cells were cultured for 5–6 days in 6-well plates (Costar). For siRNA-mediated knockdown of PTPN6, cells were washed and resuspended in antibiotic-free macrophage medium. siRNA oligos were obtained ...