We recently observed that targeting protein tyrosine phosphatase non-receptor type 22 (PTPN22), a negative immune regulator, reduces tumor growth by ∼80% in an immunotherapy-resistant model of PDAC ...

Conclusions For the first time, we report genome-wide significant association of PTPN22 (rs2476601) to PsA susceptibility, but no evidence for association to psoriasis. The aim of the current study ...

PTPN22 is the pathway of interest to Ho’s lab because it’s only expressed in hematopoietic cells. In cancer, PTPN22 expression is associated with inflammatory cells and immunoregulatory genes. Looking ...

Department of Biochemistry and Molecular Biology and Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, NAST Centre for ...

Find more information on the Altmetric Attention Score and how the score is calculated. The lymphoid tyrosine phosphatase (Lyp, PTPN22) is a critical negative regulator of T cell antigen receptor (TCR ...

Coffey’s research focuses on extracting and genotyping DNA from PEP619ww to identify the presence of mutate allele PTPN22 and for CRE + or CRE – mice. Coffey is affiliated with the Comanche ...

While both the shared epitope and the PTPN22*C1858T allele are certainly associated with RA, the question of whether these associations are primarily with susceptibility or severity has proved ...

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) has been previously linked to several chronic inflammatory disorders and it has been established that PTPN22 regulates T-cell receptor ...

Expression of the tyrosine-protein phosphatase non-receptor type 22 (PTPN22) is restricted to hematopoietic cells where it serves critical functions in regulating T-cell signaling that have made ...

Although the experimental system is limiting in addressing intracellular signaling parameters, the overall conclusions of the paper are important in that they further our understanding of the ...

Objective: Systematic review of the association of protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene 1858 and 1123 sites single nucleotide polymorphism (SNP) with the susceptibility of ...