Onvansertib targets the PLK1 isoform only (not PLK2 or PLK3), is orally administered and has a 24-hour half-life with only mild-to-moderate side effects reported. Currently, the drug is in Phase ...

Additionally, we were able to show that the engineered system could be used to regulate cellular signaling cascades by optochemically triggering overexpression of an endogenous gene, polo-like kinase ...

DOYLESTOWN, Pa., March 26, 2024 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage biopharmaceutical ...

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Importantly, ATRN-1051 is a highly potent and selective inhibitor of WEE1 that does not significantly affect off-target PLK1, PLK2 and PLK3, a family of kinases that promote M phase entry, a critical ...

Targeting substrate recognition and subcellular localization through the Polo-Box domain represents an attractive alternative to generating PLK1 specific compounds and to avoid the tumor suppressor ...

A number of protein kinases have been shown to phosphorylate SIAH2. These include serine/threonine kinases p38, HIPK2, DYPK2, CHK2, and PLK3, as well as the tyrosine kinase SRC. A recent report ...

Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin Medical University General ...

Onvansertib targets the PLK1 isoform only (not PLK2 or PLK3), is orally administered and has a 24-hour half-life with only mild-to-moderate side effects reported. Cardiff Oncology believes that ...

Identification of novel signaling mechanisms of platelet activation is essential for developing next generation anti-thrombotic therapies. Polo-like kinase 3 (Plk3) is expressed in platelets with ...

Onvansertib targets the PLK1 isoform only (not PLK2 or PLK3), is orally administered and has a 24-hour half-life with only mild-to-moderate side effects reported. Trovagene believes that targeting ...

The enzymatic activity of Plk3 increases following interaction of the CD95 receptor with its ligand. Knockout (KO) or knockdown of caspase-8, CD95 or FADD prevents activation of Plk3 upon CD95 ...