Lysosomes, responsible for recycling worn-out cellular components, are central to the survival of pancreatic cancer cells The researchers zeroed in on PIKfyve, an enzyme that regulates lysosomal ...

Scientists at the University of Michigan have discovered that inhibiting the PIKfyve enzyme prevented tumor development and reduced tumor growth by altering the lipid synthesis these cells rely on.

In a recent paper, published in Nature, researchers from the University of Michigan have discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human ...

Genetic or pharmacological inhibition of PIKfyve, a lipid kinase integral to lysosomal functioning, disrupted ferritinophagy, reducing the intracellular iron pool elevated by mTOR inhibition.

Researchers have uncovered a how INPP4B, alongside PIKfyve and TRPML-1, drives pancreatic cancer metastasis. Researchers at the University of Toronto, Toronto Metropolitan University and the Princess ...

To this end, we performed a CRISPR-Cas9 loss-of-function screen in PDAC cell lines that identified the lipid kinase PIKfyve as a gene necessary for PDAC proliferation. PIKfyve is a lipid kinase that ...

In this study, we used genome-wide CRISPR screens in spheroid culture to determine that LKB1 impairs growth via activation of the PIKFYVE lipid kinase. Furthermore, we determined that LKB1 promotes ...

Kineta. has filed a patent for compositions and methods to treat neurological disorders like ALS, frontotemporal degeneration, and Alzheimer’s disease by administering a PIKfyve inhibitor. The ...

The lipid kinase PIKfyve converts phosphatidylinositol-3-phosphate to phosphatidylinositol 3,5-bisphosphate and is required in the late stage of the autophagic pathway. Blocking PIKfyve disrupts ...