This month's cover highlights the article Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity by Bo He, Ruth Ganss and colleagues. Eribulin is an anti-cancer ...

First characterized in 2013, APDS is caused by genetic variants in either of two genes: PIK3CD or PIK3R1. These variations cause an overactive PI3K pathway, interfering with the development and ...

This study provides convincing data showing that expression of the PIK3R1(deltaExon11) dominant negative mutation in Activated PI3K Delta Syndrome 1/2 (APDS1/2) patient-derived cells reduces AKT ...

PI3K signalling mediates responses to a myriad of cues, including growth factors, hormones such as insulin, and processed antigens, and so recent discovery that genetic perturbation of PIK3R1 in ...

The syndrome is a rare primary immunodeficiency that is caused by variants in either of the PIK3CD or PIK3R1 genes, which are vital to the development and function of immune cells in the body, ...

APDS is a rare immunodeficiency disorder caused by mutations in the PIK3CD (APDS1) or PIK3R1 (APDS2) genes. “This study highlights the transformative potential of machine learning-driven predictive ...

Notably, 6 of these mutated genes (PIK3R1, HK1, NOS2, NRAS, BRAF, ITGA1) were uniquely found in adenocarcinomas” said Juan Manuel Domínguez, Head of Preclinical & Biostatistics at TOPAZIUM.

These findings suggest that the TCF3::PIK3R1 fusion may exert an inhibitory effect on PI3K-AKT signaling. A novel genetic mutation has been linked to a case of acute lymphoblastic leukemia (ALL), ...

The researchers explored in detail the role of mutations called in-frame indels in the PIK3R1-AKT pathway that have been associated with worse cancer outcomes. The researchers hypothesized that in ...

The tumors on average had 6.7 somatic mutations affecting known EC cancer-related genes, including PTEN (n=127; 79%), ARID1A (n=84; 52.5%), PIK3CA (n=81; 50.6%), CTNNB1 (n=61; 38.1%), PIK3R1 (n=59; 36 ...