In this study, we analyzed the specific molecular mechanism of Scu to improve liver histopathologic changes of MASLD rats by transcriptomics and confirmed that Pdk4 is a key target gene in SCU ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Enhanced ribosome‐ and metabolic activity is ...

Mechanistically, loss of miR‐183 and miR‐96 suppresses glucose utilization in skeletal muscle by increasing PDHA1 phosphorylation via targeting FoxO1 and PDK4. On the other hand, loss of miR‐183 and ...

We next validated the hub gene, PDK4, in a cell model of DN. We also constructed the PDK4-related PPI network to investigate the correlation between PDK4 expression and other genes.

More specifically by regulating epigenetics through histone acetylation. These studies will further examine whether loss of different PDK isoforms, specifically PDK2, but not PDK4, is cardioprotective ...

Liangpunsakul's team have identified the novel role of a protein called "Pyruvate dehydrogenase kinase 4," or PDK4, in the development of ALD, which may pave the way for new treatments.

Pyruvate Dehydrogenase Kinase 4 (PDK4) is upregulated in the muscles of patients and mice with cancer cachexia. PDK4 inhibits the enzyme responsible for the conversion of pyruvate to acetyl coenzyme A ...

In this study, we investigated the metabolic profile of FA synthesis using combination therapy of melatonin and diisopropylamine dichloroacetate (DADA), a PDK4 inhibitor, in EAE mice. Disease ...

Department of Gastrocolorectal Surgery, The First Hospital of Jilin University, Changchun, China Previous studies reported that pyruvate dehydrogenase kinase 4 (PDK4) is closely related to diabetes, ...