In a search for the kinase responsible for PDK1 Y163 phosphorylation, TIE1 was identified as a potential candidate. TIE1, a receptor tyrosine kinase, was found to be upregulated by ING5 and ...

Finally, the team had a more-or-less complete model: under normal conditions, SRC phosphorylates MAGI1, which prevents it from playing matchmaker with PP2A and S6K; inhibiting SRC with dasatinib gets ...

Interestingly, the VEGF-stimulated phosphorylation of S6K, another substrate of PDK1, was not affected by CU05-1189 (Figures 4A, B). To determine how the PDK1-mediated Akt pathway is specifically ...

Roche has synthesized pyruvate dehydrogenase kinase 1 (PDK1) inhibitors reported to be useful for the treatment of systemic lupus erythematosus, psoriasis, inflammatory bowel diseases, idiopathic ...

According to the conclusions, in leukemic stem cells, the PDK1 enzyme prevents the pyruvate from entering the mitochondrion (the organelle in charge of the cell energy production) as a metabolic ...

PDK1: a determining factor in different metabolic states. In the study, PDK1 was identified as a determining factor in different metabolic states.

The kinase PDK1 is a crucial regulator for immune cell development by connecting PI3K to downstream AKT signaling. However, the roles of PDK1 in CD4 + T cell differentiation, especially in T ...

Since the gene that codes for PDK1 is overexpressed in some cancers, the scientists expect that inhibiting it will have both anti-aging and anti-cancer effects. Reference: An S, Cho S-Y, Kang J, et al ...

Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development. It is activated in a wide variety of cancers ...

For some time, scientists have understood that a particular biochemical pathway, known as the PDK1 pathway, is active in metastasizing cancer cells. But no one knew why.

OncoKB annotates the biologic and oncogenic effects and prognostic and predictive significance of somatic molecular alterations. Potential treatment implications are stratified by the level of ...