The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

Mechanistically, Wnt3a induces O-GlcNAcylation at Serine 174 of PDK1 to stabilize the protein, resulting in increased glycolysis and osteogenesis. These findings highlight O-GlcNAcylation as an ...

Here, we use virtual screening against an ensemble of both crystal structures and comparative models to identify ligands for an allosteric peptide-binding site on the protein kinase PDK1 (the PIF ...

There are four kinases, PDK1, PDK2, PDK3 and PDK4, which can phosphorylate and inactivate PDH; and two phosphatases, PDP1 and PDP2, that dephosphorylate and activate PDH. We have analyzed by ...

PDK1: a determining factor in different metabolic states In the study, PDK1 was identified as a determining factor in different metabolic states. “PDK1 plays a determining role in the energy ...

Department of Thoracic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China In this study, first of all, the regulatory effect of SOX2-OT as a ceRNA on the ...

They then investigated one of the molecules, an enzyme called PDK1, in incubated senescent skin fibroblasts and three-dimensional skin equivalent tissue models. They found that blocking PDK1 led to ...

They then investigated one of the molecules, an enzyme called PDK1, in incubated senescent skin fibroblasts and three-dimensional skin equivalent tissue models. They found that blocking PDK1 led ...

They then used the model to predict the effects of inhibiting PDK1 in senescent cells, and confirmed the results in lab-cultured cells and skin equivalent tissue models. Professor Cho and his ...

We identify a role for a dynamic short segment in the PH domain that appears to regulate autoinhibition and PDK1-catalyzed phosphorylation of Thr308 in the activation loop. We determine that Akt ...

Increase in food intake observed in A-PDK1KO mice was partially restored in A-PDK1/FoxO1DKO mice (SI Appendix, Fig. S4D), suggesting that the amelioration of metabolic abnormalities in A-PDK1/FoxO1DKO ...

We explored the effects in young (YA, 3–4 months of age) and mature (MA, 11–14 months of age) male and female PDK1 K465E knock-in mice in a battery of tests under different anxiogenic conditions. The ...