NTS071 is an oral small molecule allosteric reactivator targeting p53 Y220C with a novel scaffold. It selectively binds to the p53 Y220C mutant protein, improving its thermal stability, thereby ...

An independent validation was performed on 914 patients. Nonmutational p53 dysfunction identifies MDS with poor outcomes that are not efficiently captured by conventional prognostic scores. These ...

Becky Burke’s move to the University of Arizona began less than three hours after the University at Buffalo women’s basketball team won the WNIT championship. UB athletic director Mark Alnutt ...

While artificial intelligence (AI) only recently exploded into the mainstream, the University at Buffalo has led innovative work in AI focused on the public good for decades. Some of the latest AI ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient ... the effect of unfolded DD on the ubiquitin-dependent reporter (Ub G76V-mCh ...

Enhanced P53 transcriptional activity ... This study suggests that the K120 Ub-H2B epigenetic modification could serve as a molecular feature (in cardiomyocytes) to predict progression to DCM. Future ...

The p53 protein plays a significant role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long dubbed the protein p53 as the “guardian of the ...

Hochul announced UB as the statewide location for Empire AI while speaking about her 2024-25 budget proposal Friday at the Center for the Arts on UB’s North Campus. As part of her announcement, Hochul ...

And now, Gov. Kathy Hochul has declared Buffalo — and specifically UB — the home of this century’s great technological innovation: artificial intelligence. Speaking Friday at the Center for the Arts, ...