Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also known as p53, which serves as a crucial cell protector.

SHANGHAI, May 4, 2025 /PRNewswire/ -- On April 23, 2025, Nutshell Therapeutics ( Shanghai) Co., LTD. received IND clearance from the FDA to initiate Phase 1 clinical trial in the United States for its ...

Furthermore, mutant p53 has been implicated in inhibiting innate immune signaling by disrupting the cGAS-STING-TBK1-IRF3 pathway (Ghosh et al., 2021).Analyzing data from various databases, we observed ...

Nonmutational p53 dysfunction identifies MDS with poor outcomes that are not efficiently captured by conventional prognostic scores. These patients typically display (1) abnormal p53 protein ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumors FMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

BUFFALO, NY – February 24, 2025 – A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled “Robust p53 phenotypes and prospective downstream targets in ...

DYRK4 acts as a scaffold protein to recruit TRIM71 and LUBAC to IRF3, ... Huang C, Zhang Y, Wu X, Lu H, and Zhou X Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53 Cell ...

CLSP-1025 targets the p53 R175H mutation, which is prevalent in a range of solid tumors such as colorectal, esophageal, gastric, gynecological, lung, pancreatic and prostate cancers.

The p53 protein variant Δ133p53α may play an important role in improving the effectiveness of chimeric antigen receptor (CAR) T cell therapy. genprowebdirectory Facebook Linkedin RSS Twitter Youtube ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Kunkalikar, Bhavana. (2023, January 27). Protein adduction and p53 tumor suppressor inhibition.

Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis.. Cancer Research , 2022; DOI: 10.1158/0008-5472.CAN-21-4390 Cite ...