However, GMCL1 knockdown did not affect cell viability or apoptosis in Taxol-treated cells with mutant p53 or inactivated p53 (HeLa and HEC-1-A, respectively) (Figure 4E-H). Figure 4. GMCL1 deficiency ...

Our view of p53 dysfunction in human cancers has been modified by the discovery of mechanisms underlying nonmutational p53 inactivation. 12-14 The majority of TP53 mutations occur as missense changes ...

The HeLa cervical cancer cell line and MBA-MD231 and MCF-7 breast cancer cell lines were transfected with pEGFP-N1-TP53@ZIF-8 and pEGFP-N1-TP53@ZIF-8-PEI nanoparticles. The ability of the p53 protein ...

The p53 protein variant Δ133p53α may play an important role in improving the effectiveness of chimeric antigen receptor (CAR) T cell therapy. genprowebdirectory Facebook Linkedin RSS Twitter Youtube ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Kunkalikar, Bhavana. (2023, January 27). Protein adduction and p53 tumor suppressor inhibition.

Evasion of apoptosis is a hallmark of cancer, but the molecular mechanisms of this process are not fully understood. Survivin, a member of the inhibitor of apoptosis gene family, is overexpressed in ...

(B) The protein levels of p53 and other proteins were detected by using Western blot with indicated antibodies. HeLa cells were transfected with RNAi–TRIM28 and wild-type Myc-MAGE-C2 followed by ...

Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis.. Cancer Research , 2022; DOI: 10.1158/0008-5472.CAN-21-4390 Cite ...

Figure 6 p53 overexpression inhibited cell proliferation, migration, invasion, and colony formation potentials in human cervical cancer cells. (A) MTT assay analysis of proliferation ability in the ...

P53 and Rb act as sentinels making sure cells don't accumulate harmful genetic mutations and stop dividing after a set number of cycles. My research has focused on how HPV proteins interact with tumor ...

Multiphoton fluorescence image of HeLa cells. (Tom Deerinck/NIH via Flickr, CC BY-NC) In an amazing twist of fate, the aggressive cervical cancer tumor that killed Henrietta Lacks, a 31-year old ...