Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also known as p53, which serves as a crucial cell protector. This protein acts a ...

No mutations were detected in IDH1/IDH2, ATRX, BRAF, P53, H3F3A, or the TERT promoter ... and concluded that CIC-DUX4 fusion transcripts induced up-regulation of multiple tumor enhancer activator 3 ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

The investigational therapy, which is designed to treat the abnormal expression of a gene called double homeobox 4 (DUX4), was also tied to a greater than 50% mean reduction across multiple DUX4 ...

Del-brax is the first investigational therapy designed to treat the underlying cause of FSHD, which is caused by the abnormal expression of a gene called double homeobox 4 or DUX4. FSHD is a rare, ...

The least squares mean change from baseline in DUX4-driven gene expression from muscle biopsy specimens did not differ significantly between the losmapimod and placebo groups (0.83 vs 0.40 ...

[Keith Chambers/Science Photo Library/Getty Images] The p53 protein plays a significant role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long ...

At Fred Hutch, a striking example of this process can be found in work of the Tapscott Lab, which devotes itself to studying an enigmatic protein called DUX4 whose complexity is nothing short of ...

In a new study published in Cell Reports led by Dr. Smith, researchers reported that DUX4 is also expressed in some cancer cell lines, but only transiently, resulting in a small percentage of cells ...

In a recent study published in the Cell Reports journal, researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition. Studies have shown that exposing esophageal cells ...

AOC 1020 is designed to reduce the expression of DUX4 mRNA and DUX4 protein in muscles. The Food and Drug Administration (FDA) has granted Fast Track designation to AOC 1020 for the treatment of ...