Monitoring apoptosis in breast cancer cells is crucial for understanding the molecular mechanisms underlying breast cancer and evaluating the therapeutic effects of anticancer drugs. Real-time ...

We first performed qRT-PCR to analyze p53 and p21 mRNA expression. ZWINT had no effect on p53 mRNA expression level and p21 expression was significantly upregulated in the ZWINT knockdown group ...

(A) SNHG9 overexpression could inhibit YBOX3 and P21 protein expression level in both the cytoplasm and nucleus tested by Western blotting. The intracellular reference was GAPDH. The internal nuclear ...

Johnson & Johnson is testing a coronavirus vaccine known as JNJ-78436735 or Ad26.COV2.S. Clinical trials showed that a single dose of the vaccine had an efficacy rate of 72 percent in the United ...

Objective: To investigate the effects of a synthetic small double-stranded RNA (dsRNA) dsP21-555 on the development of bladder cancer cell lines T24 and EJ. Methods: According to the different ...

What we found most interesting from our study was a marked increase in p21 mRNA and p21 protein levels in lungs from chronically hypoxic and SM22-5-HTT+ mice as well as cultured PA-SMC treated with ...

Objective—Carbon monoxide–releasing molecules (CORMs) represent a pharmacological alternative to CO gas inhalation. Here, we questioned whether CORM-3, a well-characterized water-soluble CORM, could ...

Premature senescence, a key strategy used to suppress carcinogenesis, can be driven by p53/p21 proteins in response to various stresses. Here, we demonstrate that Wig1 plays a critical role in this ...

The p21 mRNA levels were inversely correlated with Wig1 mRNA levels . To explore the decay rate of the p21 transcript, actinomycin D (ActD) chase and qRT–PCR assays were performed. As shown in Figure ...

Rho GTPases are central components of multiple subcellular signaling pathways and are known to regulate gene expression at the transcriptional level (4–6).Rho signaling also inhibits transcription of ...