Oligonucleotide probes are short stretches of single-stranded DNA or RNA used to detect the presence of complementary nucleic acid sequences (target sequences) by hybridization. Oligonucleotide ...

(5) Chemicals cleave the oligonucleotide and remove protecting groups. (6) Continued exposure to harsh chemicals damages the DNA and reduces yields. Scientists use short oligonucleotides as primers ...

Less than a month after researchers unveiled that a “ticking DNA clock” is behind Huntington’s disease (HD), scientists have now identified an antisense oligonucleotide (ASO) that can slow ...

The technical aspects involved with the design, synthesis and use of oligonucleotide arrays for gene expression experiments are now fairly routine. New breakthroughs will require careful ...

With its recent data drop for an oligonucleotide candidate, Dyne Therapeutics signals it may become a frontrunner in this ...

Preclinical studies have shown their potential to reduce inflammation and modulate immune responses in diseases like rheumatoid arthritis and lupus.

Therapeutic synthetic oligonucleotides face unique analytical challenges in late-stage development. Meeting stringent regulatory requirements demands highly specific and sensitive methods like LC-MS.

With the rapid increase in the development of oligonucleotide therapeutics and gene therapies ... High-resolution time-of-flight mass spectrometry (TOF-MS) can be used for this analysis offering ...

Direct chemical synthesis has been adapted to make oligonucleotides of remarkable length, including an 800 nucleotide green fluorescent protein gene and a 1728 nucleotide bacteriophage DNA polymerase ...

The model used to summarize this release may make ... to delivering a new class of RNA therapeutics called antibody oligonucleotide conjugates, and currently serves on its Board of Directors.