Mitochondrial enzymatic activity and mtDNA density measures display low between-tissue correlations across 22 tissues from 27 mice. A long-standing assumption is that mitochondrial energy capacity ...

Concerns about the AI startup DeepSeek are battering a corner of the energy market that's been vying to be the power source of choice for the booming artificial intelligence industry in the US ...

PGC-1α is a transcriptional co-activator that broadly induces metabolic genes through activation of transcription factors, such as ERR, Nrf1, Gabpa and YY1. Here we show that PGC-1α transcribes 13 ...

When proteasome activity decreases because of several reasons including chemical inhibitors and aging, the transcription factor NRF1 gets activated, leading to the upregulation of proteasome gene ...

Using bioinformatic predictions, we identified NRF1 as a new potential TF involved in the regulation of ATG5 and ATG7 and demonstrated that knockdown of NRF1 had an impact on protein and mRNA levels ...

The scientists focused on two genes: SPI1, which encodes the master transcriptional regulator PU.1 in microglia, and Nuclear Respiratory Factor (NRF1), which regulates mitochondrial function in ...

In order to maintain proteasome function, cells induce the synthesis of new proteasomes by the transcriptional factor NRF1 upon proteasome dysfunction. Interestingly, NRF1 is a glycoprotein that ...

However, the underlying mechanism is not completely understood. Here we report that PGC‐1α and nuclear respiratory factor 1 (NRF1), master regulators of mitochondrial biogenesis and metabolic ...

Mitochondrial biosynthesis regulated by the PGC-1α-NRF1-TFAM pathway is considered a novel potential therapeutic target to treat heart failure (HF). Perindopril (PER) is an angiotensin-converting ...