Background: First-line anti-EGFR therapy is one of the choice that improves outcomes in KRAS/NRAS wild-type (WT), but evidence on subsequent anti-VEGF therapy following anti-EGFR therapy remains ...

The simulations provide valuable insights into the dynamics of the KRAS and NRAS gene, revealing how specific mutations affect DNA stability and interaction with histones. By focusing on the ...

Gene Hackman's wife, Betsy Arakawa Hackman, inquired about COVID-19 and flu-like symptoms multiple times before she died, according to a report obtained by Fox News Digital. Detectives with the ...

The lab of The Wistar Institute’s Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2. The team published their findings in the ...

As part of The Wistar Institute's Melanoma Research Center, the Villanueva lab pursues new ways to overcome the challenge of melanoma drug resistance. In this paper, the group took aim at melanomas ...

The team tested their hypothesis in the lab by silencing the S6K2 gene, which successfully killed NRAS MUT melanoma cell lines known to resist MAPK inhibition.

By analyzing the downstream molecular and genetic impact of MAPK inhibition in NRAS MUT melanomas, the Villanueva team identified the gene S6K2 as a possible target. Once they assessed melanoma ...

On these bases we propose that haploinsufficiency of NRAS gene (OMIM *164790) may be important in determining the clinical phenotype of this microdeletion. Clinical report Our patient was a ...

This finding is significant because it could shift the approach to treating cancers driven by RAS gene mutations. Instead of passively blocking RAS — which has been the go-to method to date — this new ...

The Gene Editing Institute team addressed this dilemma by focusing on a short sequence of DNA code that is unique to the harmful NRAS mutation seen in melanoma patients.

The researchers focused on a mutation within the NRAS gene. In the human body, healthy NRAS genes control important, basic biological processes, like cell division.

These moles can develop into a severe type of skin cancer called melanoma. In the study, published in the Journal of Investigative Dermatology, the researchers blocked a gene called NRAS, which is ...