A recent study has revealed promising targets for treating childhood acute myeloid leukaemia (AML) driven by NUP98 fusion ...

Nup98 Protein Shields Broken DNA, Preventing Cancerous Errors Nup98 protein helps repair broken DNA by creating safe spaces, preventing mistakes that could lead to cancer.

The Nup98 discovery could have real-world impact, especially for diseases like acute myeloid leukemia, where mutations in Nup98 are known to play a role. By elucidating how Nup98 guides DNA repair, ...

A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital role in safeguarding the most vulnerable areas of DNA. By forming ...

imageimageNuclear pores complexes (NPCs) conduct nucleocytoplasmic transport in eukaryotic cells. This work introduces a nanobody toolkit for studying NPC biogenesis and describes a checkpoint that ...

SAN DIEGO, Dec. 08, 2023 (GLOBE NEWSWIRE) -- Kura Oncology, Inc. (NASDAQ: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the ...

Abstract. Background: Acute myeloid leukemia (AML) with NUP98 fusions is associated with poor prognosis in adults and especially children. Pediatric AML is a rare and heterogeneous disease ...

ORF6 directly interacts with the nucleoporin 98 (Nup98)-ribonucleic acid export 1 (Rae1) complex at the nuclear pore, disrupting bidirectional nucleo-cytoplasmic trafficking in two distinct ways.

Cellular ability to mount an enhanced transcriptional response upon repeated exposure to external cues is termed transcriptional memory, which can be maintained epigenetically through cell divisions ...