Globally, NF1 affects approximately 1 in 3000 individuals. Plexiform neurofibromas (PN), a subtype of NF1-associated tumors, occur in up to 50% of patients with NF1.

Panelists discuss how mutations in the NF1 gene lead to loss of neurofibromin function, resulting in hyperactivation of the RAS/MAPK and PI3K/AKT/mTOR pathways, and how this molecular ...

A federal jury in the Northern District of California on Wednesday convicted cryptocurrency entrepreneur Rowland Marcus Andrade of wire fraud and money laundering connected to the sale of a token ...

On an earnings call, Salom and new CEO Raymond Chun reiterated that AML remediation is the bank’s “top priority.” The Justice Department and Financial Crimes Enforcement Network jointly selected ...

The US Food and Drug Administration has approved mirdametinib for the treatment of neurofibromatosis type 1 (NF1) in adults and children. The drug, developed by SpringWorks Therapeutics ...

One of the main reasons is that regulators have moved toward a comprehensive assessment of the effectiveness of an AML system, rather than treating various AML measures and typologies separately. Thus ...

Rapid NF1-PN growth and symptom progression are typical during early childhood, but disease progression can occur at any time. Neurofibromatosis type 1 (NF1) is a genetic condition that causes ...

Neurofibromatosis type 1 (NF1) is a genetic condition that raises your risk of tumors, including benign plexiform neurofibromas (PN), which grow along tissues that cover nerves. PN often can’t ...

Researchers have discovered that an FDA-approved epilepsy drug can prevent or slow the growth of NF1-linked optic gliomas in mice, laying the groundwork for a clinical trial. A drug used to treat ...