The optimized 3D bioprinted adipose tissues rapidly promoted the migration of skin cells in vitro by modulating the expression levels of cell migration-related proteins (MMP2, COL1A1, KRT5 ...

They identified a matrix metalloproteinase-2 (MMP2)–sensitive probe that could distinguish patients with and without PDAC and used it to develop the PAC-MANN-1 assay for detecting PDAC by ...

This technology utilises biomarkers (MMP2 and MMP9), offering a non-invasive solution for early cancer detection. The test, leveraging biomarkers, claims 98.04 per cent sensitivity and 100 per cent ...

In this study, we described an “all-in-one” polymer–lipid conjugate (PEG2k-ppTAT-PEG1k-PE) that could self-assemble to matrix metalloproteinase 2 (MMP2)-sensitive multifunctional micelles. The ...

Researchers continue to explore how to turn deadly venom into life-saving drugs. Several papers on the subject have recently been published and BioSpace is taking a look at them. Researchers continue ...

As a matrix metalloproteinase, the abnormal expression of MMP2 is associated with multiple biological processes, including tissue remodeling and cancer progression. Therefore, spatial analysis of MMP2 ...

Summary: Blocking the matrix metalloproteinases MMP2 and MMP9 can have the opposite effect on neuroplasticity depending on whether the brain is healthy or injured. Source: University of Gottingen The ...

Master protocol to assess safety and recommended phase 2 dose of next generation NY-ESO-1–specific TCR T-cells in HLA-A*02 patients with synovial sarcoma or non-small cell lung cancer (Substudies 1 ...

Development of abdominal aortic aneurysm (AAA) is associated with proinflammatory cytokines including interleukin‐12 (IL12). Deficiency of interleukin 12p40 (IL12p40) increases localized fibrotic ...

Furthermore, OA/Oamb signaling requires Matrix metalloproteinase 2 (Mmp2) to activate GSC increase in the ovarian escort cells. Finally, we show that SPSNs relay the mating signal to the ...

We show that upon loss of BMP signaling, tumors lead to aberrant activation of JNK/Mmp2 signaling, followed by intestinal barrier dysfunction and commensal imbalance. In turn, the dysbiotic microbiome ...