The MitoSOX measurement was conducted according to the manufacture protocol (Yeasen Biotech, 40778ES50). Accordance with the instructions and acquired images using Cell Imaging Multi-Mode Reader ...

A complex regulatory network is known to promote functional exhaustion of CD8 + T-cells, but less is known about those factors that protect CD8 + T-cells from exhaustion. This study identifies the ...

This work highlights mitochondrial respiration as a critical metabolic dependency and an exploitable vulnerability in BTSCs. Our findings show that mubritinib efficiently crosses the blood-brain ...

Briefly, 5 µM MitoSOX Red was added to the cuvettes and the fluorescence was measured at 510-nm excitation and 579-nm emission wavelengths. Time-dependent monitoring of the MitoSOX Red-related ...

Treating diabetic sepsis (DS) can be challenging because of the persistent infection of multiple organs. To address this complicated pathological condition, it is necessary to develop advanced ...

The effects of lactylation on mitochondria function was determined through JC-1 and mitoSOX™ staining by adding exogenous lactate (10mM) and C646 (20mM) in neuronal cells. The stressed mice then were ...

Respiratory chain dysfunction can decrease ATP and increase reactive oxygen species (ROS) levels. Despite the importance of these metabolic paramet ...

Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.

Background: Radiation therapy strongly increases the risk of atherosclerotic vascular disease, such as carotid stenosis. Radiation induces DNA damage, in particular in mitochondria, but the upstream ...