Conclusions：: RES potentiates ULBP2-mediated immune eradication of BC cells by NK cells through the downregulation of miR-17-5p and concurrent activation of the MINK1/JNK/c-Jun cascade. This finding ...

The paper characterized a specific defect in the spatial working memory of mice with a deficit in a protein called Rac1. Rac1 inhibition was limited to the presynaptic compartment of neurons, which is ...

This month's cover highlights the article SIRT2 negatively regulates the cGAS‐STING pathway by deacetylating G3BP1 by Yutong Li, Fuping You, Jianyuan Luo, and colleagues. The cover image is inspired ...

This study identifies the PRAK-NRF2 axis as a novel and relative unique antioxidant pathway in Th17 cells, which have the highest expression of PRAK among CD4+ effector T cells. The disruption of PRAK ...

Misshapen like kinase 1 (MINK1) is involved in the regulation of Th17 cell differentiation, but its effect on severe asthma remains unclear. Our previous studies showed that methyl-CpG binding domain ...

Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, Ningxia, PR China Department of Emergency, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, PR China ...

Recent studies have established that CCR2 (C-C chemokine receptor type 2) marks proinflammatory subsets of monocytes, macrophages, and dendritic cells that contribute to adverse left ventricle (LV) ...

I am Professor and Consultant in Clinical Genetics in Stockholm, Sweden. Currently I am the head of the Clinical Genetics and Genomics diagnostic laboratory (Karolinska University Hospital) and group ...

The researchers were able to pinpoint two kinases, HIPK1 and MINK1, that had no previously known role in lupus. When these enzymes are targeted in follicular helper T cells, they inhibit the ...