The periaqueductal gray and upper midbrain tegmentum were however preserved. The pattern of brainstem lesions correlated with the sequelae of transtentorial shifting due to increased intracranial ...
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Measurements of midbrain atrophy including the midbrain to pons ratio, the MRPI and the MRPI 2.0 are the most robust biomarkers for clinical diagnosis of PSP-RS at the individual level (level 2).
The midbrain was measured as the area above the superior pontine line—midbrain tegmentum, while the pons was the area between the two horizontal lines of the superior and inferior notches (Figure 1A).
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