Our data demonstrated significant modulation (p < 0.05) of 337 secreted proteins in MYB-silenced MiaPaCa cells, whereas 282 proteins were differentially present in MYB-overexpressing BxPC3 cells, ...

CapG and gelsolin levels were reduced using RNA interface in Suit-2, Panc-1 and MiaPaCa-2 cells. Cell motility was assessed using modified Boyden chamber or wound-healing assays. Results: Multiple ...

TME, tumour microenvironment. AXL Increased IHC staining in 54 out of 99 (55%) PDAC tissue samples. Increased expression in Panc-1, CFPAC1, PK9, MiaPaCa-2 and SU86.86 versus HPNE cell lines. 18 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Pancreatic ductal adenocarcinoma (PDAC) is a ...

MIAPaCa-2 and PANC-1 using immunohistochemistry and multiplexed gene expression analysis. The direct anti-tumor effects of Ampligen were investigated using proliferation and migration assays after ...

Unmodified bubbles did initiate PDAC cell death. In vivo, administration of GEM-loaded MB is well tolerated. Xenograft MiaPaCa-2 PDAC tumors were grown in 60 athymic mice (12/group). Mice were then ...

A new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a ...

For the study, three PDAC cell lines (CFPAC-1, MIAPaCa-2, and PANC-1) were treated with various concentrations of Ampligen and their corresponding vehicle control. The proliferation and migration ...

Rewired metabolism is a hallmark of pancreatic ductal adenocarcinomas (PDA). Previously, we demonstrated that PDA cells enhance glycosylation precursor biogenesis through the hexosamine biosynthetic ...

AZD1775 alone decreased expression of phospho-CDC2, a marker of mitotic delay, at both time points for BxPc3, MiaPaca-2, and Panc1, and after 48 hours in L3.3. While phospho-CDC2 expression increased ...

They also performed studies with the human pancreatic cancer cell lines PATU-8988T, BxPC-3, PANC-1, and MiaPACA-2, which have no or low metastatic activity, and PATU-8988S, AsPC-1, SUIT-2, and Capan-1 ...