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Frontiers4y
A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction
The intracellular sensor, NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome, is a multimeric protein complex composed of a sensor NLRP3, an adaptor protein apoptosis-associated ...
C&EN10y
Isolation and Characterization of a Tetramethyliron(III) Ferrate: An Intermediate in the Reduction Pathway of Ferric Salts with MeMgBr
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
PNAS14y
Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity
In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring “natural product-like” macrolides, the design, synthesis, and validation of a unique class of ...
C&EN19y
An Iterative Catalytic Route to Enantiopure Deoxypropionate Subunits: Asymmetric Conjugate Addition of Grignard Reagents to α,β-Unsaturated Thioesters
A highly enantioselective (up to 96% ee) conjugate addition of Grignard reagents, in particular, MeMgBr, to α,β-unsaturated thioesters is provided as well as its application to a diastereo- and ...
PNAS21y
Copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic enones
It is no longer necessary to use dialkylzinc reagents to obtain enantioselectivities >95% in the copper-catalyzed asymmetric conjugate addition of organometallic compounds to cyclic enones. We now ...