eLife24d
Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells
This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, ...
eLife1mon
Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice
Confocal microscopy, magnification 600X. M - meiotic entry spermatocytes; L - leptotene; Ph - pachytene; PM - post-meiotic stages. To investigate molecular mechanisms of CDK8/19 mediated alterations ...
The EMBO Journal1mon
The dynamics of loss of heterozygosity events in genomes
This month's cover highlights the article RudLOV is an optically synchronized cargo transport method revealing unexpected effects of dynasore by Akiko K. Satoh, Takunori Satoh and colleagues. The ...
Frontiers3y
Tell the Difference Between Mitosis and Meiosis: Interplay Between Chromosomes, Cytoskeleton, and Cell Cycle Regulation
Meiosis is a specialized style of cell division conserved in eukaryotes, particularly designed for the production of gametes. A huge number of studies to date have demonstrated how chromosomes behave ...
Frontiers4y
Barley Anther and Meiocyte Transcriptome Dynamics in Meiotic Prophase I
Four stages were collected: pre-meiosis–G2, leptotene–zygotene, pachytene–diplotene and all stages from metaphase I to tetrad. For comparison we included four samples of germinating embryo (EMB) as ...