Here’s how it works. If you’re looking to invest in a new running watch, you might be torn between the Garmin Fenix 7 and the Garmin Fenix 7 Pro. Below, we put the two watches head-to-head to ...

The MCM2–7 hetero-hexamer is the replicative DNA helicase that plays a central role in eukaryotic DNA replication. In proliferating cells, the expression level of the MCM2–7 hexamer is kept high, ...

Finding more therapeutic targets for advanced ccRCC is an urgent mission. The minichromosome maintenance proteins 2-7 (MCM2-7) protein forms a stable heterohexamer and plays an important role in DNA ...

Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2–7 and the kinase DDK. Cohesin and its loader SCC2/4 (NIPBL/MAU2 in ...

indicates a nonspecific band. B. Wild‐type (Wt; YST1351) and cdc45‐AID (YST1400) cells were serially diluted 10 times from ˜10 7 cells/ml, and spotted and grown on the indicated plates for 2 days at ...

During G1 phase, two Cdt1-Mcm2-7 heptamers are loaded onto each replication origin by the origin-recognition complex (ORC) and Cdc6 to form an inactive MCM double hexamer (DH), but the detailed ...

Mcm2‐7 loading occurs at ORC binding sites in the absence of cyclin E/Cdk2 activity. Loading the full complement of Mcm2‐7 during G1 requires cyclin E/Cdk2 activity. Chromatin‐associated Mcm2‐7 levels ...